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Penicillin G Acylase

Minimum Order Quantity:


Packaging Details:

Sealed in plastic or cardboard drums, 25/30/40kg per barrel

Delivery Time:

Within one month after the order is completed

Payment Terms:

45 days or 90 days

Supply Ability:

10 tons/year

  • Description
Place of Origin:China
Brand Name:Hunan Nanbeiwang Biological Technology Co.,Ltd
Model Number:01

Penicillin acylase, also known as penicillin amidase or penicillin aminohydrolase.

Penicillin G acylase is a key enzyme for semi-synthetic β-lactam antibiotics. It can catalyze the hydrolysis of penicillin and its extended acid to remove side chains, and produce important intermediates of semi-synthetic β-lactam antibiotics, 6-aminopenicillanic acid (6-APA) and 7-amino-3-deacetoxy cephalosporic acid (7-ADCA). It also catalyzes the condensation of 6-APA or 7-ADCA with side chains to produce a variety of semi-synthetic β-lactam antibiotics.

The enzyme is mainly obtained from the Escherichia coli intracellular enzyme and the Bacillus megaterium extracellular enzyme, which has been widely used in industrial production of key intermediates of β-lactam antibiotics and semi-synthetic β-lactam antibiotics.


The enzyme is used for amide hydrolysis and is used for enzymatic production of key pharmaceutical intermediates such as 6-APA, 7-ANCA, 7-ATCA, D-type amino acids, chiral compound resolution and other uses.


AppearanceSlightly yellow spherical particles
Particle size≥100μm
Enzyme activity≥130U/g
β-LactamaseNot detected
Water content50-60%
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