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Ho hlahisoa ha ursodeoxycholic acid ka ho sebelisa mokhoa oa likokoana-hloko molemong oa mokhoa oa lik'hemik'hale o hlahisitsoeng ke k'hamphani ea rona ho rarollotse mathata a ts'ireletso ea tikoloho le ts'ebetso ea tlhahiso ea bareki ba rona Changde Yungang Biotechnology Co, Ltd., e ntlafalitseng haholo tlhahiso ea lihlahisoa le boleng, e fokotsehile haholo theko ea tlhahiso le phaello e eketsehileng ea moruo. Morero o ntse o etsoa indastering.

Khamphani ea rona e atlehile ho hlahloba lisebelisoa tsohle tse ncha tsa theknoloji e ncha ea ho e ntša, ho e hloekisa le ho e matlafatsa ea protheine ea enzyme ho tsoa ho libaktheria tse entsoeng ka liphatsa tsa lefutso, e rala motheo o tiileng oa tšebetso ea ursodeoxycholic acid ka mokhoa oa enzymatic. Mekhoa e metle ke e latelang:

1. Ka lekhetlo la pele, enzyme ea li-UD e sebelisoa ho ts'ebetso ea ursodeoxycholic acid. Tlhahiso ea enzymatic ea ursodeoxycholic acid e entsoe ka lik'hemik'hale ha ho bapisoa le ea pele. Mokhoa oa semi-synthesis o na le melemo ea ts'ebetso e bonolo, ts'ebetso e phahameng ea tlhahiso le ts'ireletso ea tikoloho .;

2. Sebelisa mokhoa o mocha oa ho hlatsoetsa, khetha maemo a nepahetseng a ho belisa ho fumana chai e phahameng ka ho ithuta foromo ea belisoa;

3. Ho bokella ka kotloloho li-enzyme tsa baktheria bakeng sa tlhahiso, ho nolofatsa mehato ea ho tlosa le ho itlhoekisa ea enzyme, le ho boloka ts'ebetso ea enzyme ka katleho e kholo.